化学名称 : 培美曲塞
CAS : 157716-52-4
英文名称: Perifosine/D21266 /D-21266
英文同义词: PERIFOSINE
溶解度:Soluble in water at 10mg/ml
储存条件:-20C 2 years
生物活性
Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine(D 21266 ) is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine(D 21266 ) causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5µM at 24h) and is associated with rapidly decreased Akt activation. In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.
参考文献
1 Ruiter, G.A., Zerp, S.F., Bartelink, H., et al. Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis. Cancer Res 59 2457-2463 (1999).
2 Kondapaka, S.B., Singh, S.S., Dasmahapatra, G.P., et al. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation. Molecular Cancer Therapeutics 2 1093-1103 (2003).