Chemical Name : Perifosine/D21266 /D-21266
CAS : 157716-52-4
Solubility:Soluble in water at 10mg/ml
Storage:-20C 2 years
Alkylphospholipids are a class of antineoplastic compounds that display potent antiproliferative activity in several in vitro and in vivo human tumor models. Perifosine(D 21266 ) is an alkylphospholipid that induces apoptotic cell death in a variety of tumor cell lines. Apoptosis is induced in a time- and dose-dependent manner in U937 and Jurkat T human leukemia cell lines but not in normal vascular endothelial cells. Perifosine(D 21266 ) causes inhibition of PC-3 prostate carcinoma cell growth (growth inhibition (GI50) = 5µM at 24h) and is associated with rapidly decreased Akt activation. In addition, perifosine induces p21WAF1 expression in squamous carcinoma cells through a p53-independent pathway, leading to loss in cyclin-dependent kinase activity and cell cycle arrest.
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