639089-54-6
639089-54-6
编号ABP000120
化学名称VX-680 (MK-0457)
英文名称 VX-680 (MK-0457)
MDL: MFCD13185152
分子式C23H28N8OS
分子量464.586
纯度 98%
化学名称 : VX-680 (MK-0457)
CAS : 639089-54-6
英文名称: VX-680 (MK-0457)
英文同义词: N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-cyclopropanecarboxamide
同义词: N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-cyclopropanecarboxamide
Solubility:Soluble in DMSO
Storage:-20C 2 years
Biologieal
VX-680 inhibits Aurorakinases A,B and C with Ki values of 0.6, 18 and 4.6 nM, resp. It also inhibits Flt-3 and Abl as well as their mutant forms
Reference
1Giles FJ, MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation.Blood. 2007 Jan 15;109(2):500-2.
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