MLN8054/MLN-8054

MLN8054/MLN-8054

MLN8054/MLN-8054

编号ABP000124 化学名称MLN8054/MLN-8054 CAS869363-13-3 分子式C25H15ClF2N4O2 分子量476.862 纯度 >99%

化学名称 : MLN8054/MLN-8054

CAS : 869363-13-3

英文名称: MLN8054/MLN-8054

英文同义词: 4-[[9-Chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid

溶解度:  Soluble in DMSO

储存条件:  -20C 2 years

生物活性

Aurora A inhibition using MLN8054, a selective Aurora A small-molecule inhibitor. Human tumor cells treated with MLN8054 show a high incidence of abnormal mitotic spindles, often with unseparated centrosomes.Auora kinase inhibitor MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregration, and inhibition of cell proliferation.MLN8054-treated cells frequently show alignment defects during metaphase, lagging chromosomes in anaphase, and chromatin bridges during telophase. Consistent with the chromosome segregation defects, cells treated with MLN8054 develop aneuploidy over time

参考文献

1. Hoar K, Chakravarty A, Rabino C, Wysong D, Bowman D, Roy N, Ecsedy JA. MLN8054, a small-molecule inhibitor of Aurora A, causes spindle pole and chromosome congression defects leading to aneuploidy. Mol Cell Biol. 2007 Jun;27(12):4513-25. Epub 2007 Apr 16.

询价