Cat.No.ABP000897 Chemical NameLY2940680 CAS1258861-20-9 MolFormulaC26H24F4N6O MolWeight512.502 Purity 98%

Chemical Name : LY2940680

CAS : 1258861-20-9

Synonyms: 4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)benzamide

Storage:at -20℃ 2 years


LDE225(NVP-LDE225) is a novel and specific, orally bioavailable Smo inhibitor with an IC50 of 11 nM. It has been shown to potentially inhibit Hh-and Smo-dependent proliferation in vivo. It also induced the regression of preformed basaloid lesions with an IC50 of <150 nmol/l and almost complete regression at 1.5 μmol/l. Topical application of a 1% LDE225(NVP-LDE225) solution to depilated skin of C57/BL6 mice completely inhibited hair growth during anagen phase as well as the expression of the Hh-pathway target genes (Gli1, Gli2, Sox9, and N-Myc) and partial inhibition was obtained when applying a 0.3% solution.


[1] Stuetz A. et al. Melanoma Research. 2010 6; 20: 40