Home / Products / Inhibitors / Hedgehog inhibitor / GDC-0449(Vismodegib)/GDC0449


Cat.No.ABP000894 Chemical NameGDC-0449(Vismodegib)/GDC0449 CAS879085-55-9 MolFormulaC19H14Cl2N2O3S MolWeight421.297 Purity >99%

Chemical Name : GDC-0449(Vismodegib)/GDC0449

CAS : 879085-55-9

Synonyms: 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide


An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.