Home / Products / Inhibitors / CDK inhibitors / PD-0332991/PD0332991,PD332991


Cat.No.ABP000842 Chemical NamePD-0332991/PD0332991,PD332991 CAS571190-30-2 MolFormulaC24H29N7O2 MolWeight447.5328 Purity >99%

Chemical Name : PD-0332991/PD0332991,PD332991

CAS : 571190-30-2

Synonyms: 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino] pyrido[2,3-d]pyrimidin-7-one


Storage:at -20℃ 2 years


JNJ-7706621 is a novel cell cycle inhibitor that showed potentv inhibition of several cyclin-dependent kinases (CDK) and Aurora kinases and selectively blocked proliferation of tumor cells of various origins but was about 10-fold less effective at inhibiting normal human cell growth in vitro.JNJ-7706621 slowed the growth of cells and at higher concentrations induced cytotoxicity. Inhibition of CDK1 kinase activity, altered CDK1 phosphorylation status,and interference with downstream substrates such as retinoblastoma were also shown in human tumor cells following drug treatment.


1.The In vitro and In vivo Effects of JNJ-7706621: A Dual Inhibitor of