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Cat.No.ABP000850 Chemical NameIndirubin/ CAS479-41-4 MDL: MFCD00956441 MolFormulaC16H10N2O2 MolWeight262.267 Purity >99%

Chemical Name : Indirubin/

CAS : 479-41-4

Synonyms: (2'Z)-3-(1,3-DIHYDRO-3-OXO-2H-INDOL-2-YLIDENE)-1,3-DIHYDRO-2H-INDOL-2-ONE

Solubility:Soluble to 100 mM in DMSO

Storage:Desiccate at RT


AZD 5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.


Byth et al (2009) AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2 and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol.Cancer Ther. 8 1856.