212141-51-0

溶解度:Soluble to 10 mM in DMSO

储存条件:Store at RT

生物活性

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

参考文献

1. Fry et al (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 1093.

2. Bridges et al (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 39 267.