化学名称 : N-[4-[[3-(2-氨基-4-嘧啶基)-2-吡啶基]氧基]苯基]-4-(4-甲基-2-噻吩基)-1-酞嗪胺
CAS : 945595-80-2
英文名称: AMG900/AMG-900
英文同义词: N-(4-([3-(2-Aminopyrimidin-4-yl)pyridin-2-yl]oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
PHA-680632 is the first representative of a new class of Aurora inhibitors (Aurora A/B/C IC50 at 27, 135 and 120 nM, respectively). This agent has a high potential for further development as an anticancer therapeutic.
PHA-680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses. The IC50 of PHA-680632 for cell anti-proliferation ranged from 0.11 µM to 5.6 µM.
参考文献
[1] Soncini C et al. Clin Cancer Res. 2006 Jul 1;12(13):4080-9