化学名称 : 2-(4-氨基-1-异丙基-1H-吡唑并[3,4-D]嘧啶-3-基)-1H-吲哚-5-醇
CAS : 1092351-67-1
英文名称: PP242 /PP-242
英文同义词: PP242
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
XL765(SAR245409) is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110α, β, γ and δ, respectively. It is an orally available small molecule that has been shown in preclinical studies to selectively inhibit the activity of phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR). In preclinical studies, XL765 slowed tumor growth or caused tumor shrinkage in multiple preclinical cancer models, including breast, lung, ovarian, and prostate cancers, and gliomas. XL765 has also been shown to enhance the anti-tumor effects of several chemotherapeutic agents in preclinical cancer models.
参考文献
[1] Garcia-Echeverria C et al. Oncogene. 2008 Sep 18;27(41):5511-26