2-(4-氨基-1-异丙基-1H-吡唑并[3,4-D]嘧啶-3-基)-1H-吲哚-5-醇

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2-(4-氨基-1-异丙基-1H-吡唑并[3,4-D]嘧啶-3-基)-1H-吲哚-5-醇

2-(4-氨基-1-异丙基-1H-吡唑并[3,4-D]嘧啶-3-基)-1H-吲哚-5-醇

编号ABP000904 化学名称PP242 /PP-242 CAS1092351-67-1 MDL: MFCD12196869 分子式C16H16N6O 分子量308.343 纯度 ≥98% by HPLC

化学名称 : 2-(4-氨基-1-异丙基-1H-吡唑并[3,4-D]嘧啶-3-基)-1H-吲哚-5-醇

CAS : 1092351-67-1

英文名称: PP242 /PP-242

英文同义词: PP242

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

XL765(SAR245409) is a mixed mTOR/PI3k inhibitor with IC50 of 157, 39, 113, 9 and 43 nM for mTOR, p110α, β, γ and δ, respectively. It is an orally available small molecule that has been shown in preclinical studies to selectively inhibit the activity of phosphoinositide-3 kinase (PI3K) and mammalian target of rapamycin (mTOR). In preclinical studies, XL765 slowed tumor growth or caused tumor shrinkage in multiple preclinical cancer models, including breast, lung, ovarian, and prostate cancers, and gliomas. XL765 has also been shown to enhance the anti-tumor effects of several chemotherapeutic agents in preclinical cancer models.

参考文献

[1] Garcia-Echeverria C et al. Oncogene. 2008 Sep 18;27(41):5511-26

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