GDC-0449(Vismodegib)/GDC0449

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GDC-0449(Vismodegib)/GDC0449

GDC-0449(Vismodegib)/GDC0449

编号ABP000894 化学名称GDC-0449(Vismodegib)/GDC0449 CAS879085-55-9 分子式C19H14Cl2N2O3S 分子量421.297 纯度 >99%

化学名称 : GDC-0449(Vismodegib)/GDC0449

CAS : 879085-55-9

英文名称: GDC-0449(Vismodegib)/GDC0449

英文同义词: 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide

生物活性

An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.

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