Vatalanib Dihydrochloride/

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Vatalanib Dihydrochloride/

Vatalanib Dihydrochloride/

编号ABP000870 化学名称Vatalanib Dihydrochloride/ CAS212141-51-0 MDL: MFCD08458963 分子式C20H15ClN4 分子量346.819 纯度 >99%

化学名称 : Vatalanib Dihydrochloride/

CAS : 212141-51-0

英文名称: Vatalanib Dihydrochloride/


溶解度:Soluble to 10 mM in DMSO

储存条件:Store at RT


An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.


1. Fry et al (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 1093.

2. Bridges et al (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 39 267.