1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氧基]-2-丙醇

 主页 / 产品目录 / Inhibitors / EGFR inhibitor / 1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氧基]-2-丙醇
1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氧基]-2-丙醇

1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氧基]-2-丙醇

编号ABP000860 化学名称Brivanib(BMS-540215)/BMS540215 CAS649735-46-6 MDL: MFCD13194684 分子式C19H19FN4O3 分子量370.382 纯度 >99%

化学名称 : 1-[[4-[(4-氟-2-甲基-1H-吲哚-5-基)氧基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氧基]-2-丙醇

CAS : 649735-46-6

英文名称: Brivanib(BMS-540215)/BMS540215

英文同义词: BRIVANIB

溶解度:Soluble in DMSO

储存条件:-20C 2 years

生物活性

BIBW-2992 is a potent oral, irreversible combined EGFR/HER2 inhibitor both in vitro and in vivo. The potency of BIBW-2992 on the EGFR and HER2 kinases revealed IC50 values of 0.5 nM and 14 nM, respectively. BIBW-2992 is highly selective for these kinases

参考文献

1. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Li, D., Ambrogio, L., Shimamura, T., Kubo, S., Takahashi, M., Chirieac, L.R., Padera, R.F., (...), Wong, K.-K.. 2008 Oncogene 27 (34), pp. 4702-4711(cant find full text or PDF)

2. Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Riely, G.J. 2008 Journal of Thoracic Oncology 3 (6 SUPPL 2), pp. S146-S149

3. Dual inhibition of ErbB1 (EGFR/HER1) and ErbB2 (HER2/neu). Reid A, Vidal L, Shaw H, de Bono J. Eur J Cancer. 2007 Feb;43(3):481-9. Epub 2007 Jan 8. Review.

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