靛玉红

靛玉红

靛玉红

编号ABP000850 化学名称Indirubin/ CAS479-41-4 MDL: MFCD00956441 分子式C16H10N2O2 分子量262.267 纯度 >99%

化学名称 : 靛玉红

CAS : 479-41-4

英文名称: Indirubin/

英文同义词: (2'Z)-3-(1,3-DIHYDRO-3-OXO-2H-INDOL-2-YLIDENE)-1,3-DIHYDRO-2H-INDOL-2-ONE

溶解度:Soluble to 100 mM in DMSO

储存条件:Desiccate at RT

生物活性

AZD 5438 is a potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduces the proportion of actively cycling cells in vivo.

参考文献

Byth et al (2009) AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2 and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol.Cancer Ther. 8 1856.

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