AT 7519 mesylate/

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AT 7519 mesylate/

AT 7519 mesylate/

编号ABP000846 化学名称AT 7519 mesylate/ 分子式 分子量0.0

化学名称 : AT 7519 mesylate/

CAS :

英文名称: AT 7519 mesylate/

英文同义词:

溶解度:Soluble in distilled water

储存条件:-20C 2 years

生物活性

SNS-032 (formerly BMS-387032) is a small-molecule cyclin-dependent kinase (CDK) inhibitor currently in phase I clinical trials for the treatment of B-cell malignancies and advanced solid tumors.Preclinical studies have shown that SNS-032 is a specific and potent inhibitor of CDK2, 7 and 9 which induces cell cycle arrest and apoptosis in tumor cell lines. It was shown to inhibit in vitro angiogenesis and prostaglandin E2 (PGE2) production, both strongly associated with tumorigenesis. Phase I clinical trials support the safety and tolerability of SNS-032 as evaluated in dose-escalation studies. The compound is currently administered by i.v. infusion but has shown promising potential for oral delivery.

参考文献

1. Misra RN, et al. J Med Chem. 2004 Mar 25;47(7):1719-28.

2.Ali MA, et al. Neoplasia. 2007 May;9(5):370-81.

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