神经保护药物 NXY 059

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神经保护药物 NXY 059

神经保护药物 NXY 059

编号ABP000731 化学名称NXY059/NXY-059/ CAS168021-79-2 MDL: MFCD09833648 分子式C11H13NO7S2.2Na 分子量381.336 纯度 >98%

化学名称 : 神经保护药物 NXY 059

CAS : 168021-79-2

英文名称: NXY059/NXY-059/

英文同义词: DISUFENTON SODIUM

溶解度:Soluble to 100 mM in water and to 100 mM in DMSO

储存条件:Desiccate at -20°C

生物活性

Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant.

参考文献

Peeling et al (2001) Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke. Neuropharmacology 40 433. Sydserff et al (2002) Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. Br.J.Pharmacol. 135 103. Culot et al (2009) Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study. Brain Res. 1294 144.

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