长春瑞宾

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长春瑞宾

长春瑞宾

编号ABP000672 化学名称Vinorelbine(Navelbine)/ CAS71486-22-1 MDL: MFCD00866248 分子式C45H54N4O8 分子量778.942 纯度 >99%

化学名称 : 长春瑞宾

CAS : 71486-22-1

英文名称: Vinorelbine(Navelbine)/

英文同义词: VINORELBINE

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid and an anti-mitotic chemotherapy drug. [1][2] In the breast cancer cell lines MCF-7 and MDA-MB-468, increased p38 activity was demonstrated following vinorelbine but not doxorubicin treatment, whether vinorelbine was given prior to or simultaneously with doxorubicin. Mitogen-activated protein kinase (MAPK) activity and p53 expression remained unchanged following vinorelbine treatment. [3]

参考文献

[1] http://en.wikipedia.org/wiki/Vinorelbine

[2] Ngan VK et al. Cancer Res. 2000 Sep 15;60(18):5045-51

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