化学名称 : 4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫酮-1-咪唑烷基]-2-氟-N-甲基苯甲酰胺
CAS : 915087-33-1
英文名称: MDV3100/MDV-3100
英文同义词: MDV3100
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
MDV3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. It also induces tumour cell apoptosis, and has no agonist activity.
参考文献
[1] Prof Howard I Scher MD et al. The Lancet. 2010 April; 375(9724): 1437-1446