KU55933/ATM KINASE INHIBITOR

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KU55933/ATM KINASE INHIBITOR

KU55933/ATM KINASE INHIBITOR

编号ABP000416 化学名称KU55933/ATM KINASE INHIBITOR CAS587871-26-9 分子式C21H17NO3S2 分子量395.495 纯度 >99%

化学名称 : KU55933/ATM KINASE INHIBITOR

CAS : 587871-26-9

英文名称: KU55933/ATM KINASE INHIBITOR

英文同义词: 2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

KU-55933 (2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one), an ATP-competitive inhibitor, inhibits ATM with an IC50 of 13 nmol/L and a Ki of 2.2 nmol/L. KU-55933 shows specificity with respect to inhibition of other phosphatidylinositol 3-kinase–like kinases[1] .
Exposure of cells to KU-55933 resulted in a significant sensitization to the cytotoxic effects of ionizing radiation and to the DNA double-strand break-inducing chemotherapeutic agents, etoposide, doxorubicin, and camptothecin. Derivatives of this molecule may serve as novel radio- and chemosensitizors in clinical settings[1] .
In addition,KU-55933, is capable of suppressing the replication of both wild-type and drug-resistant HIV-1[2] .

参考文献

[1] Ian Hickson et al. Cancer Res. 2004 December 15; 64(24):9152

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