RAF265(CHIR-265)/
RAF265(CHIR-265)/
化学名称 : RAF265(CHIR-265)/
CAS : 927880-90-8
英文名称: RAF265(CHIR-265)/
英文同义词: 1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine;RAF265
同义词: 1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine;RAF265
Storage:at -20℃ 2 years
Biologieal
RAF265(CHIR-265) is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. RAF is a key component of the RAS/RAF/MEK/ERK signal-transduction pathway, which controls cell proliferation, differentiation, and apoptosis in mammalian cells. Raf265 also has anti-angiogenic activity through inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2).
Reference
[1] Mordant P, et al. Mol Cancer Ther. 2010 Feb;9(2):358-68.
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