RAF 265

RAF 265

RAF 265

编号ABP000414 化学名称RAF265(CHIR-265)/ CAS927880-90-8 MDL: MFCD16659061 分子式C24H16F6N6O 分子量518.419 纯度 >99%

化学名称 : RAF 265

CAS : 927880-90-8

英文名称: RAF265(CHIR-265)/

英文同义词: 1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine;RAF265

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

RAF265(CHIR-265) is a derivative of Raf265 that is an oral, highly selective RAF and VEGFR kinase inhibitor with IC50 of of 5 to 10 μM. RAF is a key component of the RAS/RAF/MEK/ERK signal-transduction pathway, which controls cell proliferation, differentiation, and apoptosis in mammalian cells. Raf265 also has anti-angiogenic activity through inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2).

参考文献

[1] Mordant P, et al. Mol Cancer Ther. 2010 Feb;9(2):358-68.

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