AT7867/AT-7867/

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AT7867/AT-7867/

AT7867/AT-7867/

编号ABP000413 化学名称AT7867/AT-7867/ CAS857531-00-1 分子式C20H20ClN3 分子量337.846 纯度 >99%

化学名称 : AT7867/AT-7867/

CAS : 857531-00-1

英文名称: AT7867/AT-7867/

英文同义词: 4-(4-Chlorophenyl)-4-[4-(1h-pyrazol-4-yl)phenyl]piperidine

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

AT7867 is a potent and oral AKT and p70 S6 kinase inhibitor with an IC50 of 17 nM. Induction of apoptosis was detected by multiple methods in tumor cells following AT7867 treatment. Administration of AT7867 (90 mg/kg p.o. or 20 mg/kg i.p.) to athymic mice implanted with the PTEN-deficient U87MG human glioblastoma xenograft model caused inhibition of phosphorylation of downstream substrates of both AKT and p70S6K and induction of apoptosis, confirming the observations made in vitro. These doses of AT7867 also resulted in inhibition of human tumor growth in PTEN-deficient xenograft models.

参考文献

[1] Grimshaw KM et al. Mol Cancer Ther. 2010 May;9(5):1100-10.

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