伐诺司林二盐酸盐

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伐诺司林二盐酸盐

伐诺司林二盐酸盐

编号ABP000311 化学名称Vanoxerine(GBR-12909) / CAS67469-78-7 MDL: MFCD00055193 分子式C28H32F2N2O.2ClH 分子量523.492 纯度 99%

化学名称 : 伐诺司林二盐酸盐

CAS : 67469-78-7

英文名称: Vanoxerine(GBR-12909) /

英文同义词: VANOXERINE DIHYDROCHLORIDE

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Vanoxerine (GBR-12909) is a piperazine derivative which is a potent and selective DRI (dopamine reuptake inhibitor). GBR-12909 binds to the target site on the DAT ~ 500 times more strongly than cocaine, but simultaneously inhibits the release of dopamine. This combined effect only slightly elevates dopamine levels, giving vanoxerine only mild stimulant effects. Vanoxerine has been researched for use in treating cocaine dependence both as a substitute for cocaine and to block the rewarding effects.

参考文献

[1] http://en.wikipedia.org/wiki/Vanoxerine

[2] http://koso.ucsd.edu/~martin/YoungGBR12909.pdf

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