Nutlin-3/

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Nutlin-3/

Nutlin-3/

编号ABP000213 化学名称Nutlin-3/ CAS548472-68-0 MDL: MFCD11978162 分子式C30H30Cl2N4O4 分子量581.497 纯度 99%

化学名称 : Nutlin-3/

CAS : 548472-68-0

英文名称: Nutlin-3/

英文同义词: NUTLIN-3B

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

Nutlin-3 is a MDM-2 antagonist with an IC50 of 90 nM. It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.[1][2]

参考文献

[1] Secchiero P et al. Neoplasia. 2007 Oct;9(10):853-61.

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