Pyroxamide

Pyroxamide

Pyroxamide

编号ABP000151 化学名称Pyroxamide/NSC696085/NSC-696085 CAS382180-17-8 MDL: MFCD13194970 分子式C13H19N3O3 分子量265.311 纯度 >99%

化学名称 : Pyroxamide

CAS : 382180-17-8

英文名称: Pyroxamide/NSC696085/NSC-696085

英文同义词: PYROXAMIDE

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

Pyroxamide(NSC 696085) is a potent histone deacetylase inhibitor with an IC50 of 100 nM for HDAC-1. [1] In a study, administration of pyroxamide (100 or 200 mg/kg/day) to nude mice at doses that caused little evident toxicity significantly suppressed the growth of s.c. CWR22 prostate cancer xenografts. Despite the potent growth-inhibitory effects of pyroxamide in this tumor model, serum prostate-specific antigen levels in control versus pyroxamide-treated mice were not significantly different. It causes the accumulation of acetylated core histones in MEL cells cultured with the agent. Human CWR22 prostate tumor xenografts from mice treated with pyroxamide (100 or 200 mg/kg/day) showed increased levels of histone acetylation and increased expression of the cell cycle regulator p21/WAF1, compared with tumors from vehicle-treated control animals. [2]

参考文献

[1] Remiszewski SW. Curr Opin Drug Discov Devel. 2002 Jul;5(4):487-99.

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