AMG458/AMG-458/

AMG458/AMG-458/

AMG458/AMG-458/

编号ABP000135 化学名称AMG458/AMG-458/ CAS913376-83-7 MDL: MFCD17169989 分子式C30H29N5O5 分子量539.589 纯度 >98%

化学名称 : AMG458/AMG-458/

CAS : 913376-83-7

英文名称: AMG458/AMG-458/

英文同义词: 2,3-Dihydro-1-(2-hydroxy-2-methylpropyl)-n-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1h-pyrazole-4-carboxamide;AMG458

溶解度:Unknown

储存条件:at -20

生物活性

a potent, selective inhibitor of c-Met, a receptor tyrosine kinase that is often deregulated in cancer. AMG 458 was obsd. to bind covalently to liver microsomal proteins from rats and humans in the absence of NADPH. When [14C]AMG 458 was incubated with liver microsomes in the presence of glutathione and N-acetyl cysteine, thioether adducts were detected by radiochromatog

参考文献

1. Methods for the treatment of cancer

2. Combinations VEGF(R) inhibitors and hepatocyte growth factor (c-met) inhibitors for the treatment of cancer

3. Development of a high drug load tablet formulation based on assessment of powder manufacturability: moving towards quality by design

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