JNJ-38877605/JNJ38877605

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JNJ-38877605/JNJ38877605

JNJ-38877605/JNJ38877605

编号ABP000134 化学名称JNJ-38877605/JNJ38877605 CAS943540-75-8 分子式C19H13F2N7 分子量377.3502 纯度 >98%

化学名称 : JNJ-38877605/JNJ38877605

CAS : 943540-75-8

英文名称: JNJ-38877605/JNJ38877605

英文同义词: 6-[Difluoro[6-(1-methyl-1h-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]quinoline

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

c-Met inhibitor JNJ-38877605 is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antineoplastic activity. It selectively inhibits c-Met (mesenchymal-epithelial transition), a receptor tyrosine kinase (RTK) involved in cancer cell survival and invasiveness, and tumor angiogenesis.

参考文献

1. Liu X, Yao W, Newton RC, Scherle PA. Scherle.Targeting the c-MET signaling pathway for cancer therapy. Expert Opin Investig Drugs. 2008 Jul;17(7):997-1011

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