SGX-523

SGX-523

SGX-523

编号ABP000132 化学名称SGX-523 CAS1022150-57-7 分子式C18H13N7S 分子量359.408 纯度 >99%

化学名称 : SGX-523

CAS : 1022150-57-7

英文名称: SGX-523

英文同义词: 6-(6-(1-Methyl-1h-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinoline

溶解度:Unknown

储存条件:at -20C 2 years

生物活性

SGX-523, an orally bioavailable small molecule, specifically binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway. This agent has shown exceptional selectivity for the cMET receptor tyrosine kinase over more than 200 protein kinases.SGX-523 may induce cell death in tumor cells expressing c-Met in vitro and in vivo.Currently, one Phase I studies are performed to evaluate the safety, tolerability and pharmacokinetic profile of SGX523.

参考文献

1. http://203.208.39.132/search?q=cache:XczNp-GS9eIJ:usstock.jrj.com.cn/2008-01-16/000003186974.shtml+SGX-523&cd=1&hl=zh-CN&ct=clnk&gl=cn&st_usg=ALhdy2_9ZP-CEhYe4S-13yHxUfNd_oXrWg

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