CCT129202/CCT-129202

CCT129202/CCT-129202

CCT129202/CCT-129202

编号ABP000123 化学名称CCT129202/CCT-129202 CAS942947-93-5 分子式C23H25ClN8OS 分子量497.016 纯度 >99%

化学名称 : CCT129202/CCT-129202

CAS : 942947-93-5

英文名称: CCT129202/CCT-129202

英文同义词: 2-[4-[6-Chloro-2-(4-dimethylaminophenyl)-3H-imidazo[4,5-b]pyridin-7-yl]piperazin-1-yl]-N-(thiazol-2-yl)acetamide

溶解度:Unknown

储存条件:at -20℃

生物活性

CCT129202 is a Aurora kinase inhibitor with IC50 of 0.042 0.022, 0.198 0.05, and 0.227 0.064 mol/L for Aurora A, Aurora B, and Aurora C, respectively.It showed high selectivity for the Aurora kinases over a panel of other kinases tested and inhibits proliferation in multiple cultured human tumor cell lines. CCT129202 causes the accumulation of human tumor cells with 4N DNA content, leading to apoptosis. The results showed that the CCT129202 is an ATP-competitive inhibitor of recombinant Aurora A kinase with a Ki of 49.8 nmol/L. [1][2]

参考文献

[1] Chan F et al. Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3147-57 [2] Honda R et al. Mol Biol Cell. 2003 Aug;14(8):3325-4

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