VCH-759 /VCH759

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VCH-759 /VCH759

VCH-759 /VCH759

编号ABP000106 化学名称VCH-759 /VCH759 分子式C25H30NNaO4S 分子量463.56 纯度 >99%

化学名称 : VCH-759 /VCH759

CAS :

英文名称: VCH-759 /VCH759

英文同义词:

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC(50) values versus genotype 1a/1b replicons. It was well tolerated and achieved a≥2log10 decline in HCV RNA with 800 mg b.i.d. and t.i.d doses. In a subset of participants, viral rebound was observed and associated with resistant variants. This data supports further evaluation of VCH-759 in combination with interferon–ribavirin treatment. [1][2]

参考文献

[1] Cooper C et al. J Hepatol. 2009 Jul;51(1):39-46.

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