化学名称 : AS-605240/AS605240
CAS : 648450-29-7
英文名称: AS-605240/AS605240
英文同义词: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
AS-605240 is a PI3K γ inhibitor (IC50 at 8 nM), which displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. This agent is the first examples of selective PI3K γ inhibitors, and was used to block neutrophil chemotaxis in vitro and in vivo. In passive mouse models for rheumatoid arthritis these compounds minimized progression of joint destruction.
参考文献
[1] Marone R et al. Biochim Biophys Acta. 2008 Jan;1784(1):159-85