PKI587/PF-05212384,PKI-587

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PKI587/PF-05212384,PKI-587

PKI587/PF-05212384,PKI-587

编号ABP000100 化学名称PKI587/PF-05212384,PKI-587 CAS1197160-78-3 分子式C32H41N9O4 分子量615.7258 纯度 >99%

化学名称 : PKI587/PF-05212384,PKI-587

CAS : 1197160-78-3

英文名称: PKI587/PF-05212384,PKI-587

英文同义词: N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]phenyl]urea

溶解度:DMSO

储存条件:-20C,two years

生物活性

PF-05212384 (PKI-587) is a potent and selective dual PI3K/mTOR inhibitor in clinical trials.it has
shown excellent activity in vitro and in vivo, with antitumor efficacy in both subcutaneous and orthotopic
xenograft tumor models when administered intravenously

参考文献

1. Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5'-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compound 26 (PKI-587), a Highly Efficacious Dual Inhibitor

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