956906-93-7

PF-04217903 mesylate/PF04217903 mesylate

956906-93-7

编号ABP000137 化学名称PF-04217903 mesylate/PF04217903 mesylate 英文名称 PF-04217903 mesylate/PF04217903 mesylate 分子式C20H18N8O3S 分子量450.474 纯度 >99%

化学名称 : PF-04217903 mesylate/PF04217903 mesylate

CAS : 956906-93-7

英文名称: PF-04217903 mesylate/PF04217903 mesylate

英文同义词: 2-(4-(1-(Quinolin-6-ylmethyl)-1h-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1h-pyrazol-1-yl)ethanol methanesulfonate

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

An orally bioavailabe tyrosine kinase inhibitor, targeting MET (or c-MET); it selectively binds to and inhibits mesenchymal epithelial transition (low nM Ki values and >1000 fold selective relative to 208 kinases) with potential antineoplastic activity.

参考文献

SL Timofeevski et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry. 2009, 48(23), 5339-49.

询价