化学名称 : PF-04217903 mesylate/PF04217903 mesylate
CAS : 956906-93-7
英文名称: PF-04217903 mesylate/PF04217903 mesylate
英文同义词: 2-(4-(1-(Quinolin-6-ylmethyl)-1h-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1h-pyrazol-1-yl)ethanol methanesulfonate
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
An orally bioavailabe tyrosine kinase inhibitor, targeting MET (or c-MET); it selectively binds to and inhibits mesenchymal epithelial transition (low nM Ki values and >1000 fold selective relative to 208 kinases) with potential antineoplastic activity.
参考文献
SL Timofeevski et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry. 2009, 48(23), 5339-49.