941678-49-5

鲁索替尼

941678-49-5

编号ABP000833 化学名称鲁索替尼 英文名称 INCB018424(Ruxolitinib)/Ruxolitinib MDL: MFCD12031592 分子式C17H18N6 分子量306.365 纯度 >99%

化学名称 : 鲁索替尼

CAS : 941678-49-5

英文名称: INCB018424(Ruxolitinib)/Ruxolitinib

英文同义词: (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

AZD1480 is a novel potent small JAK2 inhibitor with an IC50 of  0.26 nM. Inhibition of Jak2 activity is associated with abrogation of Stat3 nuclear translocation and tumorigenesis. AZD1480 suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity. [1] AZD1480 inhibited the phosphorylation of Stat5 with an IC50 of 46 nM in TEL-Jak2 cells, whereas little or no inhibition of Stat5 phosphorylation was observed in the TEL-Jak3, TEL-Jak1, or TEL-Tyk2 cells at or below 1 μM AZD1480.

参考文献

[1] http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01219543

询价