929095-18-1

GSK461364/GSK-461364

929095-18-1

编号ABP000820 化学名称GSK461364/GSK-461364 英文名称 GSK461364/GSK-461364 分子式C27H28F3N5O2S 分子量543.604 纯度 >99%

化学名称 : GSK461364/GSK-461364

CAS : 929095-18-1

英文名称: GSK461364/GSK-461364

英文同义词: 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide

储存条件:-20℃

生物活性

AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. It significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer.

参考文献

[1] Morgan MA et al. Cancer Res. 2010 Jun 15;70(12):4972-81

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