711019-86-2

MRS2578/MRS-2578

711019-86-2

编号ABP000139 化学名称MRS2578/MRS-2578 英文名称 MRS2578/MRS-2578 MDL: MFCD07370141 分子式C20H20N6S4 分子量472.684 纯度 >95 %

化学名称 : MRS2578/MRS-2578

CAS : 711019-86-2

英文名称: MRS2578/MRS-2578

英文同义词: MRS 2578

溶解度:Soluble to 100 mM in DMSO

储存条件:at -20℃ 2 years

生物活性

Selective antagonist of P2Y6 nucleotide receptors; IC50 values are 37 and 98 nM at human and rat P2Y6 receptors respectively. Displays no activity at P2Y1, P2Y2, P2Y4 and P2Y11 receptors (IC50 > 10 μM). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.
 

参考文献

Mamedova et al (2004) Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem.Pharmacol. 67 1763. Wihlborg et al (2006) Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. Circ.Res. 98 970. Koizumi et al (2007) UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446 1091.

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