677297-51-7

TG100-115

677297-51-7

编号ABP000107 化学名称TG100-115 英文名称 TG100-115 分子式C18H14N6O2 分子量346.3428 纯度 >99%

化学名称 : TG100-115

CAS : 677297-51-7

英文名称: TG100-115

英文同义词: 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

TG100-115, inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM, respectively), whereas both PI3Kα and -β were relatively unaffected (IC50 values>1 μM). As a gauge of general specificity, TG100-115 was also assayed against a 133 protein kinase panel, none of which was inhibited at IC50 values <1 μM. [ 2,3] TG100-115 is applied to anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). TG100-115 could reduce inflammation and mucin accumulation

参考文献

[1] http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 [2] John Doukas et al. Proc Natl Acad Sci U S A. 2006 December 26;103(52):19866-71 [3] John Doukas et al. The Journal of Pharmacology and Experimental Therapeutics. 2009 March;328(3):758-765
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