化学名称 : 二氯醋酸二异丙胺
CAS : 660-27-5
英文名称: Diisopropylammonium dichloroacetate/
英文同义词: DIISOPROPYLAMMONIUM DICHLOROACETATE
溶解度:Soluble to 100 mM in DMSO
储存条件:Desiccate at +4°C
生物活性
CB2 antagonist/inverse agonist (Ki = 31.2 nM) that displays 165-fold selectivity over CB1 receptors. Behaves as a weak partial/inverse agonist at CB1 receptors.
参考文献
Hosohata et al (1997) AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. Life Sci. 61 PL115. PMID: 9284087.
Hosohata et al (1997) AM630 antagonism of cannabinoid-stimulated [35S]GTPγS binding in the mouse brain. Eur.J.Pharmacol. 321 R1. PMID: 9083796.
Landsman et al (1998) AM630 is an inverse agonist at the human cannabinoid CB1 receptor. Life Sci. 62 PL109. PMID: 9496703.