660-27-5

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二氯醋酸二异丙胺

660-27-5

编号ABP000811 化学名称二氯醋酸二异丙胺 英文名称 Diisopropylammonium dichloroacetate/ MDL: MFCD00868288 分子式C6H15N.C2H2Cl2O2 分子量230.133 纯度 >98%

化学名称 : 二氯醋酸二异丙胺

CAS : 660-27-5

英文名称: Diisopropylammonium dichloroacetate/

英文同义词: DIISOPROPYLAMMONIUM DICHLOROACETATE

溶解度:Soluble to 100 mM in DMSO

储存条件:Desiccate at +4°C

生物活性

CB2 antagonist/inverse agonist (Ki = 31.2 nM) that displays 165-fold selectivity over CB1 receptors. Behaves as a weak partial/inverse agonist at CB1 receptors.

参考文献

Hosohata et al (1997) AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. Life Sci. 61 PL115. PMID: 9284087.

Hosohata et al (1997) AM630 antagonism of cannabinoid-stimulated [35S]GTPγS binding in the mouse brain. Eur.J.Pharmacol. 321 R1. PMID: 9083796.

Landsman et al (1998) AM630 is an inverse agonist at the human cannabinoid CB1 receptor. Life Sci. 62 PL109. PMID: 9496703.

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