648450-29-7

AS-605240/AS605240

648450-29-7

编号ABP000101 化学名称AS-605240/AS605240 英文名称 AS-605240/AS605240 分子式C12H7N3O2S 分子量257.268 纯度 >99%

化学名称 : AS-605240/AS605240

CAS : 648450-29-7

英文名称: AS-605240/AS605240

英文同义词: 5-(6-Quinoxalinylmethylene)-2,4-thiazolidinedione

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

AS-605240 is a PI3K γ inhibitor (IC50 at 8 nM), which displays 30-fold selectivity over PI3Kδ and PI3Kβ and 7.5-fold selectivity over PI3Kα. This agent is the first examples of selective PI3K γ inhibitors, and was used to block neutrophil chemotaxis in vitro and in vivo. In passive mouse models for rheumatoid arthritis these compounds minimized progression of joint destruction.

参考文献

[1] Marone R et al. Biochim Biophys Acta. 2008 Jan;1784(1):159-85

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