648449-76-7

AS-604850

648449-76-7

编号ABP000113 化学名称AS-604850 英文名称 AS-604850 分子式C11H5F2NO4S 分子量285.224 纯度 >99%

化学名称 : AS-604850

CAS : 648449-76-7

英文名称: AS-604850

英文同义词: 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione

溶解度:Unknown

储存条件:at -20℃ 2 years

生物活性

AS-604850  is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 0.25, >20, >20, and 4.5 µM for the human recombinant γ, δ, β, and α isoforms, respectively. AS-604850  shows no notable activity against a wide array of protein kinases at 1 μM. AS-604850  inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg. [1][2]

参考文献

[1] Rameh LE et al. J Biol Chem. 1999 Mar 26;274(13):8347-50.

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