635728-49-3

Darunavir Ethanolate(Prezista)/TMC114

635728-49-3

编号ABP000914 化学名称Darunavir Ethanolate(Prezista)/TMC114 英文名称 Darunavir Ethanolate(Prezista)/TMC114 分子式C29H43N3O8S 分子量593.732 纯度 >99%

化学名称 : Darunavir Ethanolate(Prezista)/TMC114

CAS : 635728-49-3

英文名称: Darunavir Ethanolate(Prezista)/TMC114

英文同义词: [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate ethanol

溶解度:Soluble in water

储存条件:-20C 2 years

生物活性

Raltegravir targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV.

参考文献

1. Potent inhibitors of HIV-1 integrase display a two-step, slow-binding inhibition mechanism which is absent in a drug-resistant T66I/M154I mutant. Garvey, E.P., Schwartz, B., et al. 2009 Biochemistry 48 (7), pp. 1644-1653

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