化学名称 : PD-0332991/PD0332991,PD332991
CAS : 571190-30-2
英文名称: PD-0332991/PD0332991,PD332991
英文同义词: 6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino] pyrido[2,3-d]pyrimidin-7-one
溶解度:DMSO
储存条件:at -20℃ 2 years
生物活性
JNJ-7706621 is a novel cell cycle inhibitor that showed potentv inhibition of several cyclin-dependent kinases (CDK) and Aurora kinases and selectively blocked proliferation of tumor cells of various origins but was about 10-fold less effective at inhibiting normal human cell growth in vitro.JNJ-7706621 slowed the growth of cells and at higher concentrations induced cytotoxicity. Inhibition of CDK1 kinase activity, altered CDK1 phosphorylation status,and interference with downstream substrates such as retinoblastoma were also shown in human tumor cells following drug treatment.
参考文献
1.The In vitro and In vivo Effects of JNJ-7706621: A Dual Inhibitor of