化学名称 : PNU120596/PNU-120596
CAS : 501925-31-1
英文名称: PNU120596/PNU-120596
英文同义词: N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea
溶解度:Unknown
储存条件:at -20℃ 2 years
生物活性
Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (EC50 = 216 nM), with no detectable effect on α4β2, α3β4 and α9α10 receptors. Active in vivo following systemic administration
参考文献
Hurst et al (2005) A novel positive allosteric modulator of the a7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J.Neurosci. 25 4396.