化学名称 : 甲苯磺酸索拉非尼
CAS : 475207-59-1
英文名称: Sorafenib Tosylate(Bay 43-9006)/
英文同义词: SORAFENIB TOSYLATE
溶解度:Unknown
储存条件:at -20℃ 2 years
生物活性
UK 383367 is a novel, potent procollagen C-proteinase (PCP) inhibitor with an IC50 of 44 nM. In the fibroplasia model, UK 383367 inhibited deposition of insoluble collagen by 76 ± 2% at 10 μM. UK 383367 was very effective at penetrating human skin in vitro with a transepidermal delivery flux of 1.5 μg/cm2/h, which compares favorably with values for agents that are known to penetrate skin well in vivo.UK 383367 is used for the treatment of post-surgical dermal scarring. UK 383367 is selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 >10 μM for them).
参考文献
[1] Fish PV et al. J Med Chem. 2007 Jul 26; 50(15):3442-56.
[2] Allan GA et al. Xenobiotica. 2006 May; 36(5):399-418.