332012-40-5

Telatinib(BAY57-9352)/BAY57-9352

332012-40-5

编号ABP000891 化学名称Telatinib(BAY57-9352)/BAY57-9352 英文名称 Telatinib(BAY57-9352)/BAY57-9352 分子式C20H16ClN5O3 分子量409.826 纯度 >97%

化学名称 : Telatinib(BAY57-9352)/BAY57-9352

CAS : 332012-40-5

英文名称: Telatinib(BAY57-9352)/BAY57-9352

英文同义词: 4-[[[4-[(4-Chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide

溶解度:DMSO

储存条件:at -20℃ 2 years

生物活性

Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. Pelitinib irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. Pelitinib inhibits EGF-induced phosphorylation of EGF-R and the growth of tumors that overexpress EGF-R in animal models.

参考文献

[1] http://clincancerres.aacrjournals.org/content/14/1/215.full.pdf+html

询价