300816-15-3

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RS-504393

300816-15-3

编号ABP000463 化学名称RS-504393 英文名称 RS-504393 分子式C25H27N3O3 分子量417.5002 纯度 98%

化学名称 : RS-504393

CAS : 300816-15-3

英文名称: RS-504393

英文同义词: 6-Methyl-1'-[2-(5-methyl-2-phenyl-4- oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piper idin]-2(1H)-one

溶解度:#000000">Solubility: Soluble to 10 mM in DMSO

储存条件:Store at -20°C

生物活性

Extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.

参考文献

Mirzadegan et al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 275 25562. Furuichi et al (2003) CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J.Am.Soc.Nephrol. 14 2503. Kitagawa et al (2004) Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am.J.Pathol. 165 237.

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